Abcam, ab221808, Anti-TOR1AIP2 antibody

Size: 100µL
Rabbit Polyclonal TOR1AIP2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TOR1AIP2 also known as LAP2 or Lamina-associated polypeptide 2 is a protein associated with the nuclear envelope. The mass of TOR1AIP2 is approximately 50 kDa. It binds to lamins and chromatin playing a role in nuclear envelope organization. Expressed in various tissues this protein is present in significant amounts in cells undergoing division. TOR1AIP2 localizes mainly in the inner nuclear membrane where it interacts with other components to maintain nuclear structure.
Biological function summary
TOR1AIP2 contributes to nuclear architecture and chromatin organization by forming part of the inner nuclear membrane complex. It helps to tether chromatin to the nuclear envelope ensuring proper chromatin organization. This function is important for DNA replication and chromosome segregation during mitosis. TOR1AIP2 as part of this complex supports the structural integrity of the nucleus and facilitates processes like gene expression regulation.
Pathways
TOR1AIP2 plays roles in pathways related to nuclear envelope composition and stability. It participates in the nuclear envelope assembly pathway alongside proteins such as Emerin and Lamin B. These interactions contribute to the dynamic restructuring of the nuclear envelope during cell division. It also interacts with the nuclear lamina which is vital for maintaining nuclear shape and mechanical stability.
TOR1AIP2 shows associations with muscular dystrophies and cardiomyopathies. Mutations or misregulation of TOR1AIP2 can impact nuclear envelope integrity leading to disorders such as Emery-Dreifuss muscular dystrophy. This happens through its interaction with proteins like Lamin A/C which are also important in maintaining normal nuclear function and structure. Understanding these associations helps in developing therapeutic approaches for nuclear envelope-related diseases.