Abcam, ab221918, Anti-Phosphatidic acid phosphatase type 2B antibody

Size: 100µL
Rabbit Polyclonal Phosphatidic acid phosphatase type 2B antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLPP3 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PLPP3 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O14495

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Phosphatidic acid phosphatase type 2B also known as PAP2B or Lipin-2 plays an important role in lipid metabolism by converting phosphatidic acid to diacylglycerol. This enzyme has a molecular mass of about 47 kDa. It is mainly expressed in liver brain and adipose tissues playing a significant role in regulating lipid levels within these areas. Its activity affects the production and breakdown of fats indicating its importance in metabolic processes.
Biological function summary
This enzyme mediates lipid homeostasis and energy metabolism which are critical for cellular functions. It does not form part of a complex but works by reducing phosphatidic acid levels influencing the signaling pathways that control cell growth and differentiation. By managing lipid synthesis and degradation it helps maintain an equilibrium in lipid-related signaling processes. The conversion it catalyzes influences membrane dynamics and organelle formation.
Pathways
The enzyme actively participates in the glycerolipid biosynthesis and insulin signaling pathways. In the glycerolipid biosynthesis pathway it interacts with related enzymes like acyl-CoA synthetase and diacylglycerol acyltransferase to regulate fatty acid processing. Its role in the insulin signaling pathway affects glucose uptake by modulating lipid signals that dictate metabolic responses to insulin aligning with other vital metabolic proteins like AMPK.
Abnormal levels or function of phosphatidic acid phosphatase type 2B have links to metabolic disorders such as obesity and type 2 diabetes. This enzyme also relates to familial partial lipodystrophy which involves abnormal fat deposition in the body. Its connection to these conditions involves proteins such as perilipin which regulates lipid storage and adiponectin which is involved in insulin sensitivity further demonstrating its significance in lipid and glucose metabolism.