Abcam, ab221925, Anti-MTHFD1L antibody

Size: 100µL
Rabbit Polyclonal MTHFD1L antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MTHFD1L aa 200-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MTHFD1L aa 200-350. The exact immunogen used to generate this antibody is proprietary information.Q6UB35

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MTHFD1L also known as methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like functions as an enzyme participating in folate metabolism. With an approximate mass of 105 kDa MTHFD1L is active in the mitochondria. This enzyme facilitates the interconversion of tetrahydrofolate derivatives supporting the folate-mediated one-carbon metabolic pathway. MTHFD1L shows expression in various tissues with a noticeable presence in liver and embryonic tissues where it has roles in embryogenesis and tissue-specific functions.
Biological function summary
MTHFD1L catalyzes reactions converting methylene-THF to methenyl-THF and then to formyl-THF utilizing NADP+ as a cofactor. It does not function as a standalone component; instead it may operate as part of a larger complex engaged in one-carbon metabolism. Its activity contributes to the synthesis of important biomolecules such as nucleotides and amino acids emphasizing its role in DNA synthesis and repair.
Pathways
The folate-mediated one-carbon metabolism uses MTHFD1L to manage one-carbon units. This enzyme's function fits into the folate pathway important for nucleotide biosynthesis. It connects to other proteins such as MTHFD1 and SHMT1 which also partake in folate metabolism supporting interconnected biochemical pathways in various cellular processes.
Defects or alterations in MTHFD1L are linked to neural tube defects and some cancers. The enzyme's involvement in embryonic development and DNA repair suggests that mutations or dysregulation may contribute to these conditions. MTHFD1 and SHMT1 related proteins have similar associations highlighting their collective impact on disease when there is impaired folate metabolism.