Abcam, ab221964, Anti-Oct6 antibody

Size: 100µL
Rabbit Polyclonal Oct6 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human POU3F1 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human POU3F1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q03052

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Oct6 also known as Pou3f1 is a transcription factor with a molecular mass of approximately 45 kDa. It functions as a DNA-binding protein that influences gene expression during development. Oct6 belongs to the POU domain transcription factor family which plays a significant role in regulating specific genes across different cellular contexts. This protein is expressed mainly in the nervous system specifically in oligodendrocytes Schwann cells and some sensory organs reflecting its involvement in neural development.
Biological function summary
Oct6 regulates important developmental processes by controlling the timing and progression of myelination in the peripheral nervous system. It is a part of a multi-protein complex that includes other transcription factors necessary for glial cell differentiation. Oct6 acts by promoting the expression of genes essential for the development and function of the myelin sheath thereby maintaining proper nerve conduction and insulation.
Pathways
Oct6 interacts within the myelination process specifically the Sonic Hedgehog signaling and WNT pathways. These pathways govern the regulation of cell growth and differentiation important for neural development. Oct6 also shows interaction with other proteins like Sox10 a fellow transcription factor important for Schwann cell development enhancing its regulatory influence in neurogenesis.
Oct6 links to conditions such as Charcot-Marie-Tooth disease and Dejerine-Sottas syndrome both affecting peripheral nerves. These disorders often result from malfunction in myelination processes which Oct6 directly influences. The protein collaborates with Sox10 and EGR2 another transcription factor vital in myelination thereby implicating it in neuropathic disease mechanisms. Understanding these interactions may help develop therapeutic strategies for demyelinating diseases.