Abcam, ab221990, Anti-Surf6 antibody

Size: 100µL
Rabbit Polyclonal SURF6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SURF6 aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SURF6 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.O75683

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Surf6 also known as SURF-6 or Surfeit locus protein 6 is a protein that acts mechanically within the cell nucleus. It is approximately 37 kDa in size and shows a nuclear localization. Surf6 expression takes place in a variety of cell types where it is often located in the nucleolus suggesting its role in ribosomal functions.
Biological function summary
Within the nucleolus Surf6 associates with rRNA processing and ribosome biogenesis. It serves as a nucleolar protein with a function in facilitating the maturation and assembly of pre-rRNA into functional ribosomal subunits. Surf6 is not known to form part of a larger complex but shows interactions with other nucleolar components implying a regulatory role in ribosome production.
Pathways
Elements involving Surf6 participate in the ribosome biogenesis pathway and the cell cycle regulation pathway. Surf6 has a documented association with the RNA polymerase I machinery which is important for rRNA transcription. Its function aligns with nucleolar proteins like nucleolin and fibrillarin which also regulate ribosomal RNA synthesis and processing.
Alterations in Surf6 expression or mutation can link to proliferative diseases such as cancer. Surf6's role in ribosome biogenesis ties it to tumors where excessive ribosome production supports uncontrolled cell division. Connections are evident with other proteins like p53 known for tumor suppressor activities highlighting Surf6's potential impact on cellular proliferation in oncogenic contexts.