Abcam, ab222020, LM22A-4, neurotrophic BDNF mimetic

Size: 10mg / 50mg
MW 339.34 Da, Purity >98%. Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB, activating TrkB signaling. Displaces BDNF (IC 50 = 47 nM) in binding assays. Prevents neuronal degeneration with equal efficacy to that of BDNF in in vitro models of neurodegenerative disease. Causes hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats, after in vivo administraton. Improves respiratory function in a mouse model of Rett syndrome.
Key facts
CAS number:37988-18-4,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:339.34 Da,
Molecular formula:C15H21N3O6,
PubChem:2054170,
Nature:Synthetic,
Solubility:Soluble in water to 100 mMSoluble in DMSO to 100 mM,
Biochemical name:1-N,3-N,5-N-tris(2-hydroxyethyl)benzene-1,3,5-tricarboxamide,
Biological description:Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB, activating TrkB signaling. Displaces BDNF (IC50 = 47 nM) in binding assays. Prevents neuronal degeneration with equal efficacy to that of BDNF in in vitro models of neurodegenerative disease. Causes hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats, after in vivo administraton. Improves respiratory function in a mouse model of Rett syndrome.,
Canonical smiles:C1=C(C=C(C=C1C(=O)NCCO)C(=O)NCCO)C(=O)NCCO,
InChi:InChI=1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24),
InChiKey:RGWJKANXFYJKHN-UHFFFAOYSA-N,
IUPAC Name:1-N,3-N,5-N-tris(2-hydroxyethyl)benzene-1,3,5-tricarboxamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C