Abcam, ab222058, Anti-GANP antibody

Size: 100µL
Rabbit Polyclonal GANP antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MCM3AP aa 700-850.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MCM3AP aa 700-850. The exact immunogen used to generate this antibody is proprietary information.O60318

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GANP also known as Germinal Center Associated Nuclear Protein and encoded by the MCM3AP gene is a protein with a molecular mass of approximately 210 kDa. GANP shows expression in various tissues most notably in germinal center B cells within lymphoid organs. It also appears in other cell types but at lower levels. The structure of GANP reflects its multifunctional role in cellular processes particularly in the context of immune function and cell cycle regulation.
Biological function summary
The GANP protein plays an essential role in DNA replication and repair mechanisms. It contributes to immune responses by facilitating the maturation of antibody-producing B cells. GANP functions as a part of a larger protein complex often associating with other nucleic acid-binding proteins. Its activity supports somatic hypermutation and class switch recombination processes critical for the diversification of the antibody repertoire.
Pathways
GANP integrates into the DNA replication pathway and the antigen receptor-mediated signaling pathway. In the DNA replication pathway GANP works alongside proteins like MCM3 and other components of the replication machinery to ensure accurate DNA synthesis. In the context of immune signaling GANP interacts with various signaling molecules enhancing adaptive immune responses through its regulatory functions.
GANP involvement connects primarily to immunological diseases and certain cancers. Aberrations in GANP function or expression can associate with autoimmune disorders due to its impact on immune cell regulation. In cancers GANP expression has been observed in malignancies where it may contribute to unchecked cellular proliferation. The MCM3 protein a close functional associate of GANP highlights its role in pathways that when disrupted potentially lead to tumorigenesis and other immune-related pathologies.