Abcam, ab222074, Anti-K34 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal K34 antibody. C-terminal. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KRT34 aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KRT34 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O76011

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
K34 also known as Histone H3 lysine 34 is a post-translational modification found on histone proteins. It plays a role in DNA packaging and gene expression regulation. K34 has a molecular weight of approximately 17 kDa when part of the histone complex. Researchers observe its expression in various tissues especially in actively dividing cells such as those in the bone marrow and lymphoid tissues. Its presence indicates active transcription and chromatin remodeling.
Biological function summary
This histone modification influences chromatin structure and function impacting gene expression. K34 is a part of the histone code which directs DNA-related processes like replication and repair. As part of a histone complex it interacts with other histone modifications to regulate transcription. K34 acts as a signal for recruiting chromatin remodeling complexes that facilitate the accessibility of DNA to transcription machinery.
Pathways
K34 participates in chromatin remodeling and cellular differentiation pathways. It plays a role in the epigenetic regulation of gene expression. This occurs through its interplay with other proteins like HP1 which recognizes histone modifications and modulates chromatin structure accordingly. K34 influences how transcription factors access DNA by altering chromatin conformation within regulatory pathways of gene expression.
Aberrant K34 modification associates with certain types of cancers and developmental disorders. In cancers like leukemia K34 dysregulation can disrupt normal gene expression contributing to uncontrolled cell growth. In developmental disorders alterations in K34 may affect normal cellular differentiation and tissue development. Protein interactions with K34 such as HP1 and chromatin assembly factors can influence how these diseases develop or progress due to their role in maintaining proper chromatin structure and function.