Abcam, ab222316, Anti-PACS2 antibody

Size: 100µL
Rabbit Polyclonal PACS2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PACS2 aa 350-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PACS2 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q86VP3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PACS2 also known as Phosphofurin Acidic Cluster Sorting Protein 2 functions as an integral membrane-associated sorting protein within cells. It weighs approximately 102 kDa. The protein is expressed widely with specific presence noted in the cytoplasm and mitochondria. Its role predominantly lies in modulating the trafficking and localization of various proteins contributing to cellular homeostasis and maintenance.
Biological function summary
PACS2 regulates cellular death pathways and mitochondrial dynamics by balancing pro- and anti-apoptotic signals. It forms part of the larger regulatory complexes that modulate interactions between organelles particularly affecting endoplasmic reticulum-mitochondria communication. This regulation influences apoptosis autophagy and calcium signaling playing an important role in cellular health and stress responses.
Pathways
The PACS2 protein plays significant roles in pathways such as calcium homeostasis and the mitochondrial apoptosis pathway. It interacts with proteins like Bax and Bak which are essential for apoptotic processes. PACS2's function directly impacts cellular survival pathways by modulating calcium transfer between the endoplasmic reticulum and mitochondria showing its importance in signal transduction and energy metabolism.
PACS2 is connected to neurodegenerative diseases such as Alzheimer's disease and metabolic disorders like diabetes. In Alzheimer's the protein's dysregulation affects mitochondrial function and neuronal survival implicating it in the pathogenesis. It also interacts with proteins such as amyloid precursor protein in Alzheimer's highlighting its role in neurodegenerative disease processes. In diabetes altered PACS2 activity affects insulin signaling and mitochondrial function making it a potential target for therapeutic interventions.