Abcam, ab222860, Anti-SH3BP5 antibody

Size: 50µL
Rabbit Polyclonal SH3BP5 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH3BP5 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SH3BP5 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O60239

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SH3BP5 also known as SH3-domain binding protein 5 or Bnk is a protein with a molecular weight of approximately 51 kDa. It is expressed in various tissues including the brain liver and heart. This protein negatively regulates protein kinase C (PKC) signaling by inhibiting its phosphorylation. SH3BP5 has a modular structure that allows it to interact with specific SH3 domains enabling it to participate in diverse signaling processes within the cell.
Biological function summary
SH3BP5 plays a significant role in cellular signal transduction networks. It acts as an adaptor protein facilitating interactions between different signaling molecules. SH3BP5 is known to be an important part of complexes that regulate both cellular development and stress responses. By interacting with different partners it influences processes like cell growth differentiation and response to external stimuli.
Pathways
SH3BP5 integrates its function within key signaling pathways such as the mitogen-activated protein kinase (MAPK) pathway and the PKC pathway. These pathways are essential for various cellular functions including gene expression and cellular proliferation. SH3BP5 interacts with proteins like RAF-1 in the MAPK pathway modulating downstream signaling events. It also associates with PKC isoforms affecting their activity and stability in cells.
SH3BP5 has connections to neurological disorders and cancer. Alterations in SH3BP5 expression or function can disrupt normal signaling pathways contributing to the development and progression of these conditions. In cancer SH3BP5's connection to PKC and RAF-1 pathways highlights its potential role in oncogenic processes. In neurological disorders its involvement in neuronal signaling suggests a potential impact on diseases involving neuronal communication. Understanding these associations could provide valuable insights into therapeutic strategies.