Abcam, ab223043, Anti-GOLGA3 antibody

Size: 50µL
Rabbit Polyclonal GOLGA3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Golgin subfamily A member 3 aa 200-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Golgin subfamily A member 3 aa 200-450. The exact immunogen used to generate this antibody is proprietary information.Q08378

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GOLGA3 protein also known as Golgin subfamily A member 3 is a structural protein located in the Golgi apparatus. GOLGA3 has a mass of about 170 kDa. Researchers found its expression in various cell types but it has enhanced expression in testes. GOLGA3 participates in maintaining the structural integrity of the Golgi apparatus where it helps tether and organize the Golgi membrane stacks ensuring proper protein and lipid trafficking within the cell.
Biological function summary
GOLGA3 contributes to the assembly and function of the Golgi structure and is part of a complex network of Golgi-associated proteins. This network is involved in intracellular vesicle movement and membrane trafficking. GOLGA3 interacts with other golgin members to facilitate transport processes critical for maintaining cellular homeostasis affecting the secretory pathway and protein sorting within the cell.
Pathways
GOLGA3 plays roles in the Golgi transport and vesicle-mediated transport pathways. It is associated with proteins such as RABs which are small GTPases regulating vesicle movement and COPI which assists in retrograde Golgi-to-ER transport. Through these interactions GOLGA3 influences the functionality of these pathways particularly those engaged in the dynamic processes of cargo sorting and ER-to-Golgi transport.
Researchers link GOLGA3 to certain reproductive and neurological conditions. In testicular tissue dysregulation of GOLGA3 could contribute to conditions like infertility due to its role in spermatogenesis. It also connects to Alzheimer's disease where its interaction with the amyloid precursor protein (APP) may influence APP trafficking and processing. Understanding the link between GOLGA3 and these diseases may uncover new therapeutic possibilities.