Abcam, ab223055, Anti-SCIN antibody

Size: 50µL
Rabbit Polyclonal SCIN antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SCIN aa 550 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SCIN aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y6U3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes->95% pure, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCIN also known as scinderin or adseverin is an actin-severing protein involved in cytoskeletal dynamics. This protein has a mass of approximately 80 kDa. SCIN is expressed in a variety of tissues including neural hematopoietic and endocrine systems. Its mechanical function includes binding to filamentous actin and promoting severing which helps in the reorganization of the actin cytoskeleton. This activity is calcium-dependent making SCIN responsive to intracellular calcium levels.
Biological function summary
SCIN influences cellular processes like secretion motility and division. SCIN belongs to the gelsolin/villin family of actin-modulating proteins and often acts within a protein complex to disassemble actin filaments. It regulates exocytosis by modulating actin dynamics near the plasma membrane especially in cells such as chromaffin cells and platelets. Its ability to rearrange actin filaments is important for maintaining cellular homeostasis and responsive adaptation to environmental changes.
Pathways
SCIN is involved in the cytoskeletal signaling and calcium signaling pathways. It plays a role in actin filament dynamics and is related to other actin-binding proteins like gelsolin and cofilin through these pathways. SCIN interacts with phosphatidylinositol 45-bisphosphate (PIP2) and calcium ions which are important for its activity in cellular signaling networks. These pathways optimize how cells react to stimuli by altering their shape and function.
SCIN has been linked to neurodegenerative disorders and cancer. Disruptions in SCIN function can contribute to diseases such as Alzheimer's where abnormal actin dynamics impact neuronal function. SCIN is also associated with certain cancers through its role in cell migration and metastasis. The protein may interact with tau in neurodegenerative disorders and it interacts with proteins like cortactin in cancer progression influencing cellular motility.