Abcam, ab223071, Anti-C4orf26 antibody

Size: 50µg / 50µL
Rabbit Polyclonal C4orf26 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ODAPH aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ODAPH aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q17RF5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C4orf26 also known as Chromosome 4 Open Reading Frame 26 is a relatively small protein with an estimated mass of approximately 110 kDa. This protein appears in various tissues but shows significant expression in tooth-related tissues. Researchers have noted its involvement in teeth development suggesting a specialized role in dental structures. Understanding C4orf26's mechanical function can help shed light on its broader biological role.
Biological function summary
C4orf26 participates in enamel formation critical for tooth health. C4orf26 functions within the cells that contribute to enamel mineralization assisting in the proper deposition and alignment of enamel crystals. It is not recognized as a part of any larger protein complex and acts independently in its function within the enamel matrix. This unique functionality allows it to directly influence the physical characteristics of teeth.
Pathways
C4orf26 engages within the pathways controlling mineralized tissue formation. It works alongside other proteins including amelogenin (AMELX) and ameloblastin (AMBN) in the pathway responsible for tooth enamel development. Additionally its expression appears connected to factors involved in biomineralization pathways which include other structural proteins that orchestrate the complex process of hard tissue generation in the body.
C4orf26 mutations have links to amelogenesis imperfecta a disorder impacting enamel formation leading to defective and discolored teeth. Amelogenesis imperfecta ties C4orf26 to other enamel proteins such as enamelin (ENAM) which when mutated can result in similar dental anomalies. These associations emphasize the importance of C4orf26 in maintaining enamel integrity and suggest that any disruptions in this protein could lead to significant dental health issues.