Abcam, ab223175, Anti-p26 antibody

Size: 100µL
Rabbit Polyclonal p26 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMED3 aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMED3 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q9Y3Q3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The p26 protein also known as HSPB1 or heat shock protein beta-1 plays a mechanical role by acting as a molecular chaperone primarily involved in stabilizing unfolded proteins and aiding in protein folding. This protein has a molecular mass of approximately 27 kDa. Researchers find p26 expressed in various tissues with higher levels observed in stress-responsive tissues such as heart skeletal muscle and brain. Its expression can increase under stress conditions such as heat shock oxidative stress and exposure to toxic substances.
Biological function summary
P26 helps in cell protection by preventing apoptosis and maintaining cellular homeostasis. This protein functions as part of a small heat shock protein complex operating alongside HSPB5 and other chaperones. The complex assists in modulating the actin cytoskeleton and participates in the refolding of denatured proteins thereby protecting cells from potential damage. The anti-apoptotic role of p26 further highlights its significance in cellular survival under stress conditions.
Pathways
P26 significantly involves itself in the MAPK/ERK pathway and the apoptosis signaling pathway. In the MAPK/ERK pathway p26 interacts with various kinases and modulates cell growth and differentiation processes. It also binds to cytochrome c in the apoptosis signaling pathway inhibiting the apoptosome formation and lowering the chances of cell death. Proteins like HSP70 which participates in the MAPK/ERK pathway often work in conjunction with p26 to enhance cellular stability.
P26 relates to neurodegenerative diseases and cancers. Altered expression of p26 can contribute to the development of Alzheimer's disease as it affects cellular stress responses and protein aggregation. In cancer p26 overexpression often associates with resistance to chemotherapy making it a potential target for therapeutic interventions. The interaction of p26 with proteins like HSP90 plays a role in cancer progression by stabilizing client proteins involved in cell proliferation and survival.