Abcam, ab223601, PFI-2, SETD7 histone lysine methyltransferase inhibitor

Size: 5mg / 25mg
MW 499.5 Da, Purity >98%. A potent and selective SETD7 histone lysine methyltransferase inhibitor. K i = 0.33 nM and IC 50 = 2 nM against SETD7. It displays > 1000-fold selectivity against DNMT1 and many other methyltransferases. No activity against 134 ion channel, GPCR, and enzyme targets (<35% inhibition at 10 μM). PFI-2 potently inhibits SETD7 in MCF7 cells.
Key facts
CAS number:1627676-59-8,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:499.5 Da,
Molecular formula:C23H25F4N3O3S,
PubChem:71300326,
Nature:Synthetic,
Biochemical name:8-Fluoro-N-{(2r)-1-Oxo-1-(Pyrrolidin-1-Yl)-3-[3-(Trifluoromethyl)phenyl]propan-2-Yl}-1,2,3,4-Tetrahydroisoquinoline-6-Sulfonamide,
Biological description:A potent and selective SETD7 histone lysine methyltransferase inhibitor. Ki = 0.33 nM and IC50 = 2 nM against SETD7. It displays > 1000-fold selectivity against DNMT1 and many other methyltransferases. No activity against 134 ion channel, GPCR, and enzyme targets (<35% inhibition at 10 μM). PFI-2 potently inhibits SETD7 in MCF7 cells.,
Canonical smiles:C1CCN(C1)C(=O)C(CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC4=C(CNCC4)C(=C3)F,
Isomeric smiles:C1CCN(C1)C(=O)[C@@H](CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC4=C(CNCC4)C(=C3)F,
InChi:InChI=1S/C23H25F4N3O3S/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2/t21-/m1/s1,
InChiKey:JCKGSPAAPQRPBW-OAQYLSRUSA-N,
IUPAC Name:8-fluoro-N-[(2R)-1-oxo-1-pyrrolidin-1-yl-3-[3-(trifluoromethyl)phenyl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B1259 PFI-2. B1259-25 is the same size as the 25 mg size of ab223601.
Protect from air.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark