Abcam, ab223602, PFI-3, bromodomain and SMARCA4 inhibitor

Size: 5mg / 25mg
MW 321.4 Da, Purity >98%. Potent and selective inhibitor of Polybromo (Kd = 48 nM) and SMARCA4 (K d = 89 nM). Also inhibits SMARCA2. Displays high specificity for Family VIII bromodomains. PFI-3 displays selectivity against a range of other kinases. In a panel of 103 receptors and enzymes, activity was observed only against 4 GPCRs. At a concentration of 1 μM, PFI-3 accelerates FRAP recovery in cells.
Key facts
CAS number:1819363-80-8,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:321.4 Da,
Molecular formula:C19H19N3O2,
PubChem:78243717,
Nature:Synthetic,
Biochemical name:(E)-1-(2-hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one,
Biological description:Potent and selective inhibitor of Polybromo (Kd = 48 nM) and SMARCA4 (Kd = 89 nM). Also inhibits SMARCA2. Displays high specificity for Family VIII bromodomains. PFI-3 displays selectivity against a range of other kinases. In a panel of 103 receptors and enzymes, activity was observed only against 4 GPCRs. At a concentration of 1 μM, PFI-3 accelerates FRAP recovery in cells.,
Canonical smiles:C1C2CN(C1CN2C3=CC=CC=N3)C=CC(=O)C4=CC=CC=C4O,
Isomeric smiles:C1[C@@H]2CN([C@H]1CN2C3=CC=CC=N3)/C=C/C(=O)C4=CC=CC=C4O,
InChi:InChI=1S/C19H19N3O2/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19/h1-10,14-15,23H,11-13H2/b10-8+/t14-,15-/m1/s1,
InChiKey:INAICWLVUAKEPB-QSTFCLMHSA-N,
IUPAC Name:(E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2895 PFI-3. 2895-25 is the same size as the 25 mg size of ab223602.
Protect from air.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark