Abcam, ab223776, Anti-hHR23b antibody

Size: 100µL
Rabbit Polyclonal hHR23b antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RAD23B aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RAD23B aa 200-300. The exact immunogen used to generate this antibody is proprietary information.P54727

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The human Rad23 homolog B (hHR23b) also known as RAD23B is a protein involved in DNA repair mechanisms. It weighs approximately 43 kDa and is expressed in several tissues including the skin lungs and kidneys. Mechanically hHR23b is important in the process of nucleotide excision repair (NER) where it helps recognize and repair UV-induced DNA damage. hHR23b interacts with other proteins to facilitate the repair process by removing bulky DNA lesions.
Biological function summary
HHR23b plays an important role in maintaining genomic stability. It forms a complex with xeroderma pigmentosum group C (XPC) protein which is instrumental in identifying DNA damage. This complex functions as the initial damage sensor in the NER pathway. By participating in this multiprotein complex hHR23b facilitates the recruitment of other DNA repair factors ultimately ensuring the fidelity of DNA replication.
Pathways
HHR23b is instrumental in NER and proteasome degradation. In the NER pathway it functions alongside the XPC protein to initiate the repair of damaged DNA. Through its interaction with the proteasome system hHR23b is also involved in the ubiquitin-proteasome pathway which regulates protein degradation. This dual involvement in pathways links hHR23b to both DNA repair and the regulation of protein turnover.
HHR23b is associated with cancer and neurodegenerative conditions. The malfunction or altered expression of hHR23b can lead to impaired DNA repair promoting oncogenic transformations and cancer progression specifically through its association with the XPC protein. Furthermore its role in protein degradation connects hHR23b to neurodegenerative diseases like Parkinson's where protein accumulation contributes to disease progression. Understanding these connections helps in devising therapeutic strategies targeting hHR23b and its related pathways.