Abcam, ab223785, Anti-CYP2A13 antibody

Size: 100µL
Rabbit Polyclonal CYP2A13 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Cytochrome P450 2A13 aa 350-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Cytochrome P450 2A13 aa 350-450. The exact immunogen used to generate this antibody is proprietary information.Q16696

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP2A13 also known as Cytochrome P450 2A13 is an enzyme encoded by the CYP2A13 gene located on chromosome 19. The enzyme has a molecular mass of approximately 56 kDa. It functions in the oxidation of various endogenous and exogenous compounds including the metabolism of toxins such as nicotine. CYP2A13 is prominently expressed in tissue such as the respiratory tract especially in the nasal mucosa and lung tissues as well as in the liver to a lesser extent.
Biological function summary
CYP2A13 influences the metabolic processing of xenobiotics. It belongs to the cytochrome P450 superfamily which is a group of enzymes essential for drug metabolism and the synthesis of cholesterol steroids and other lipids. While it does not form a complex itself it actively contributes to bioactivation processes that convert chemical compounds into reactive intermediates. This role is important for how the body handles and processes potential toxins or therapeutic drugs.
Pathways
The enzyme plays a notable role in the metabolism of xenobiotics by cytochrome P450. This pathway is key in converting lipophilic compounds into hydrophilic products for easier excretion. CYP2A13 is also involved in the metabolism of nicotine making it a part of the broader nicotine degradation pathway. It shares functional similarities with other cytochrome P450 family members like CYP2A6 which also participates in nicotine metabolism.
CYP2A13 has been linked to respiratory-related conditions such as lung cancer due to its involvement in the metabolic activation of tobacco-specific nitrosamines. The enzyme converts these compounds into DNA-damaging agents increasing cancer risk. Furthermore its expression in the lung tissue suggests a potential impact on other respiratory diseases. CYP2A13's metabolic activities overlap with those of CYP1A2 another enzyme related to carcinogen activation highlighting their combined relevance in tobacco-related cancers.