Abcam, ab223850, Anti-FOXC1 antibody [EPR20678]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal FOXC1 antibody. Suitable for IP, WB, Flow Cyt (Intra), IHC-P and reacts with Human, Mouse, Rat samples. Cited in 10 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20678,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXC1 also known as Forkhead box C1 is a transcription factor with a molecular mass of approximately 56 kilodaltons. This protein belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXC1 primarily expresses in tissues like the eye brain and kidneys. It plays an important role in regulating gene expression by binding to specific DNA sequences affecting the transcription of genes involved in a variety of cellular processes.
Biological function summary
FOXC1 plays a significant role in the development and differentiation of cells particularly in the anterior segment of the eye and in neural crest-derived tissues. Although it does not usually form part of a larger complex FOXC1 frequently interacts with other transcription factors and co-factors to modulate gene expression. It influences cell proliferation migration and apoptosis ensuring correct tissue and organ formation during development.
Pathways
FOXC1 contributes extensively to the regulation of developmental pathways particularly the Wnt signaling pathway. It also aligns with the Hedgehog signaling pathway which is well-known for its role in developmental processes. FOXC1 often interacts with related proteins such as FOXC2 another forkhead family member that helps orchestrate cellular events during development through these pathways.
FOXC1 mutations or dysregulation associate with disorders such as Axenfeld-Rieger syndrome and glaucoma. These conditions highlight the importance of FOXC1 in eye development. FOXC2 often appears in discussions of these conditions due to its shared role in the pathways orchestrating developmental processes. Dysregulation of FOXC1 can also influence factors such as ECM components and signaling molecules leading to pathological changes observed in these disorders.