Abcam, ab224054, Anti-PGRMC1 antibody

Size: 100µL
Rabbit Polyclonal PGRMC1 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PGRMC1 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PGRMC1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.O00264

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PGRMC1 also known as the Progesterone Receptor Membrane Component 1 plays several roles in cellular physiology. This protein weighs around 28 kDa and is expressed across various tissues including liver lung and kidney. Commonly found in the cell membrane PGRMC1 impacts tumor growth and development due to its role in several cellular functions like signal transduction and cholesterol metabolism.
Biological function summary
PGRMC1 interacts with other proteins to influence cell cycle regulation and apoptosis. It is part of protein complexes that include Cytochrome P450 enzymes. These complexes aid in regulating steroidogenesis and drug metabolism. PGRMC1’s involvement in lipid homeostasis and membrane trafficking suggests its significant role in maintaining cell health and function.
Pathways
PGRMC1 integrates into the mevalonate pathway influencing cholesterol synthesis and steroidogenesis. It interacts with proteins such as CYP51A1 and is involved in the Wnt signaling pathway. These interactions affect cellular growth and differentiation linking PGRMC1 to pathway regulation and cellular stress responses.
Researchers associate PGRMC1 with cancer progression and neurological disorders. Its overexpression relates to various cancers augmenting tumorigenic potential. Additionally PGRMC1’s connection to Alzheimer’s disease involves interactions with amyloid precursor proteins. These links highlight PGRMC1’s potential as a therapeutic target in these conditions.