Abcam, ab224098, Anti-PFTK1 antibody

Size: 100µL
Rabbit Polyclonal PFTK1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CDK14 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CDK14 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.O94921

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PFTK1 also known as PFTAIRE protein kinase 1 or CDK14 belongs to the cyclin-dependent kinase family. It has a molecular mass of approximately 36 kDa. PFTK1 is expressed in various tissues with high levels in the brain and testis. This kinase plays a role in cell cycle regulation by phosphorylating specific substrates influencing cellular processes related to proliferation and growth.
Biological function summary
PFTK1 regulates the cell cycle particularly during the G2/M transition. It does not form traditional cyclin-CDK complexes which sets it apart from other known CDKs. Instead PFTK1's activity relies on its interaction with a range of non-cyclin proteins. By aiding cell cycle progression PFTK1 impacts cellular differentiation and neuronal development which highlights its importance in neural tissues.
Pathways
PFTK1 participates in the Wnt signaling pathway and the neuronal differentiation pathway. In the Wnt pathway PFTK1 interacts with proteins that modulate beta-catenin signaling such as GSK-3β. These interactions influence transcriptional activity and cellular proliferation. The kinase's involvement in neuronal differentiation suggests its importance in neural precursor development and maturation.
PFTK1 has connections to cancer and neurodegenerative diseases. PFTK1 overexpression is often observed in cancers like gliomas suggesting its role in tumorigenesis. PFTK1 associates with Cyclin D3 in some cancers influencing tumor growth and progression. Furthermore altered PFTK1 activity impacts neuronal survival and function linking it to disorders such as Alzheimer's disease.