Abcam, ab224162, Anti-CPEB4 antibody - N-terminal

Size: 100µL
Rabbit Polyclonal CPEB4 antibody. N-terminal. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CPEB4 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CPEB4 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q17RY0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CPEB4 also known as Cytoplasmic Polyadenylation Element Binding Protein 4 plays an important role in post-transcriptional regulation specifically in mRNA polyadenylation. This protein with a molecular weight of about 75 kDa is part of the CPEB family. Researchers have discovered its expression in various tissues including the brain and testes where it binds mRNA to control translation during processes like oocyte maturation and synaptic plasticity.
Biological function summary
The protein influences gene expression by modulating mRNA stability and translational efficiency. CPEB4 is not isolated in function; it interacts with other proteins as a part of the cytoplasmic polyadenylation complex. Through these interactions CPEB4 affects cell cycle progression stress responses and neuronal development therefore integrating environmental signals into cellular responses.
Pathways
The function of CPEB4 fits into critical signaling routes including the MAPK and PI3K-AKT pathways. Within these pathways CPEB4 interacts with proteins like MEK and AKT impacting cell survival growth and differentiation. The protein modulates mRNA translation in response to signaling cues serving as a conduit for transmitting intracellular messages that dictate cellular adaptation and response.
Researchers have linked CPEB4 to conditions such as cancer and neurodegenerative diseases. In glioblastoma for example the protein's aberrant expression affects tumorigenesis pathways often in conjunction with proteins like P53 to manipulate cell proliferation and survival. In neurodegenerative conditions alterations in CPEB4 can impact proteins involved in synaptic maintenance thereby contributing to cognitive decline and neural dysfunction.