Abcam, ab224375, Anti-Testin antibody

Size: 100µL
Rabbit Polyclonal Testin antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TES aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TES aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q9UGI8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Testin also known as TES is a protein with a mass of approximately 47 kDa. It functions as a scaffold protein involved in various cellular processes including cell adhesion and cytoskeletal organization. Testin predominantly localizes at cell-cell and cell-extracellular matrix adhesions providing structural stability and support. Expression of Testin occurs in numerous human tissues with higher levels in kidneys testes and pancreas suggesting its diverse role across the body.
Biological function summary
Testin plays a major role in regulating cell communication and morphology. It integrates into larger protein complexes that modulate focal adhesion dynamics and tissue architecture. By interacting with actin filaments and other cytoskeletal proteins Testin contributes to the maintenance of cell shape and motility. Its presence in complexes highlights its role in supporting cellular infrastructure and response to environmental signals.
Pathways
Testin participates notably in the integrin signaling and actin cytoskeleton rearrangement pathways. It acts as an important link between signaling molecules and structural components within cells. Interactions with proteins such as vinculin and paxillin lead to changes in cell adhesion and migration. These pathways are important because they connect cellular mechanics to responses influencing how cells move and bind in different contexts.
Testin is linked to cancer progression and neurodegenerative conditions. Altered expression of Testin has associations with tumor metastasis where it connects to proteins like FAK and Src which are known for driving cancer cell invasion. In neurodegenerative diseases Testin's role in maintaining cytoskeletal integrity and synaptic function suggests it might have protective or detrimental effects depending on its expression and interaction with proteins like tau or amyloid-beta.