Abcam, ab224503, Anti-PTHLH antibody

Size: 100µL
Rabbit Polyclonal PTHLH antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTHLH aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PTHLH aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P12272

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Parathyroid hormone-like hormone (PTHLH) also known as PTHrP is a protein made by the PTHLH gene. It weighs around 17 kDa and its expression occurs in many tissues including the bone skin and developing structures during embryogenesis. PTHLH interacts with parathyroid hormone receptors offering actions similar to parathyroid hormone (PTH). This interaction helps to extend its role beyond classical calcium homeostasis to include other functions such as growth and developmental processes.
Biological function summary
PTHLH plays a role in cartilage development and endochondral bone formation. It functions as a significant regulator of cellular proliferation and differentiation especially in chondrocytes and osteoblasts. PTHLH can also act as part of multiprotein complexes that influence transcription and intracellular signaling. Furthermore it possesses diverse roles including smooth muscle contraction mammary gland development and cellular differentiation inhibition.
Pathways
Alongside related proteins like Indian Hedgehog (IHH) PTHLH resides in pathways critical for skeletal development and homeostasis. Notably the PTHLH/PTHR1 signaling pathway regulates chondrocyte maturation during bone growth. This pathway intersects with the Hedgehog pathway to form a regulatory loop essential for maintaining the growth plate's development and maturation. PTHLH also influences the Wnt signaling pathway associated with bone density and health.
PTHLH has connections with certain cancers specifically breast cancer and hypercalcemia of malignancy. In cancerous tissues PTHLH can be overexpressed leading to increased osteoclastic bone resorption contributing to cancer-associated conditions. Additionally PTHLH overactivity links it to familial benign hypercalcemia through its interactions with PTH and its receptors. Understanding these associations could offer therapeutic targets for treatment.