Abcam, ab224603, Anti-FBXO3 antibody

Size: 50µL
Rabbit Polyclonal FBXO3 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FBXO3 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FBXO3 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q9UK99

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein FBXO3 also known as F-box only protein 3 plays a significant role in targeting proteins for ubiquitination and subsequent degradation. Its molecular weight approximates 47 kDa and it functions in various tissues across the human body. FBXO3 forms part of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is essential for the process of tagging unwanted proteins for destruction in the proteasome.
Biological function summary
FBXO3 regulates protein stability within the cell. As a component of the SCF complex it specifically recognizes substrates that need degradation contributing to protein turnover and homeostasis. This FBXO3-mediated regulation is important for controlling the levels of various cellular proteins impacting processes like cell cycle progression and signal transduction. Its ability to interact with multiple substrates helps maintain cellular functions and responses to environmental stimuli.
Pathways
FBXO3 takes part in ubiquitin-dependent proteolysis and is closely related to the NF-kB signaling pathway. It regulates the degradation of proteins that modulate the NF-kB pathway which is essential for immune response and inflammation. It also associates with proteins like SKP1 and CUL1 within the SCF complex facilitating substrate recognition and ubiquitination and ultimately impacting cellular signaling pathways through protein turnover.
FBXO3 has implications in inflammatory disorders and certain cancers. Dysregulation in FBXO3-mediated protein degradation affects the stability of proteins involved in inflammation potentially leading to pathological states like chronic inflammatory conditions. FBXO3 also connects to the protein BTK in relation to signal transduction in some cancers providing potential targets for therapeutic interventions. Understanding the function and regulation of FBXO3 may offer insights into disease mechanisms and treatment strategies.