Abcam, ab224729, Anti-TLK2 antibody

Size: 50µL
Rabbit Polyclonal TLK2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TLK2 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TLK2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q86UE8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TLK2 also known as Tousled-like kinase 2 plays a role as a serine/threonine kinase responsible for phosphorylating proteins involved in chromatin remodeling. It has a molecular mass of approximately 90 kDa. TLK2 expresses mainly in proliferative tissues like testes and ovaries highlighting its involvement in cell proliferation processes. This kinase also shows up in other tissues where cell division is active assisting in DNA repair and cell cycle control mechanisms.
Biological function summary
TLK2 acts as a modulator of chromatin assembly by interacting with the ASF1 proteins forming a critical complex in cellular processes. Its activity is essential for the proper progression of the S-phase during the cell cycle. This function connects TLK2 to the maintenance of genomic stability largely through regulating histone incorporation. Such interactions are necessary for the preservation of the genomic integrity during DNA replication.
Pathways
TLK2 significantly impacts cell cycle regulation and DNA damage response pathways. Its participation in the cell cycle pathway intersecting with other kinases is evident as it influences the activity of proteins like CHK1 impacting the G2/M checkpoint. TLK2's involvement in the DNA damage response closely related to the ATM/ATR signaling pathway positions it as an essential player in responding to DNA insults and maintaining cell survival during stress.
TLK2 links closely with cancer especially involving ovarian and testicular tumors where aberrant expression or mutations contribute to uncontrolled cell proliferation. Mutations in TLK2 also have associations with developmental disorders influencing proteins like ASF1B with potential impacts on cognitive development. Understanding TLK2's role in these contexts provides essential insights into potential therapeutic strategies targeting dysregulated cellular processes.