Abcam, ab226001, Anti-TIP49A antibody

Size: 100µL
Rabbit Polyclonal TIP49A antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human RUVBL1 aa 200-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RUVBL1 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.Q9Y265

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab226001 was affinity purified using an epitope specific to TIP49A immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TIP49A also known as RUVBL1 or Pontin is a 54 kDa protein that plays a mechanical role in various cellular processes. TIP49A functions as an ATPase with a part in the regulation of the chromatin structure and remodeling. It is expressed in the nucleus and cytoplasm of many cell types indicating its broad involvement in cellular activities. Being highly evolutionarily conserved TIP49A shows a strong degree of structural conservation which hints at its essential roles maintained across species.
Biological function summary
TIP49A contributes to the assembly and function of multiprotein complexes. It works closely as part of the INO80 and TIP60 chromatin remodeling complexes which are important for transcription regulation and DNA repair. Through these associations TIP49A is key in controlling access to DNA impacting gene expression and stability of chromosomes. Its role in mediating interactions between different protein partners underlines its importance in maintaining cellular homeostasis and response to DNA damage.
Pathways
TIP49A participates in essential cellular processes like transcriptional regulation and DNA repair. In the context of transcription regulation TIP49A operates alongside MYC a well-known oncogene to influence gene expression linked to cell proliferation. It also plays a significant role in the homologous recombination repair pathway interacting with proteins like RAD51 to ensure proper repair of DNA double-strand breaks. These pathways demonstrate the integral function of TIP49A in preserving genomic integrity and normal cell cycle progression.
TIP49A has links to cancer progression and neurodegenerative diseases. Overexpression of TIP49A is observed in various cancers including breast and colorectal cancer where it correlates with tumor growth and poor prognosis. It interacts with c-Myc a protein with significant oncogenic potential to drive aberrant cell proliferation. In neurodegenerative conditions such as Alzheimer's disease TIP49A's connection to chromatin remodeling dysregulation is of interest although research is still ongoing to fully elucidate this relationship.