Abcam, ab226003, Anti-SNM1A antibody

Size: 100µL
Rabbit Polyclonal SNM1A antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DCLRE1A aa 400-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DCLRE1A aa 400-500. The exact immunogen used to generate this antibody is proprietary information.Q6PJP8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab226003 was affinity purified using an epitope specific to SNM1A immobilized on solid support, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SNM1A also known as three-prime repair exonuclease 1 (TREX1) is a DNA repair enzyme with exonuclease activity. It plays an important role in the removal of DNA lesions and is important for maintaining genomic stability. The protein weighs approximately 109 kDa and is expressed in various tissues with higher expression in the bone marrow and lymphoid tissues. SNM1A cleaves DNA substrates aiding in DNA repair processes.
Biological function summary
SNM1A participates in DNA damage response and repair. It functions as part of the DNA interstrand cross-link repair and processes stalled replication forks. SNM1A does not form part of a larger protein complex but works alongside other proteins like FANCD2 and FANCI. Its activity is essential for preventing DNA damage accumulation which may lead to cell death or cancerous growths.
Pathways
SNM1A operates in the Fanconi anemia pathway facilitating the repair of interstrand cross-links which are critical obstacles to DNA replication. It associates with components like the SLX4 complex and the FANCD2-FANCI complex helping resolve replication issues. Another important pathway includes the homologous recombination repair interconnecting SNM1A with RAD51 a protein important in the exchange of genetic material for accurate DNA repair.
SNM1A is linked to predispositions in certain cancers due to its role in maintaining genomic integrity. Dysfunction in SNM1A activity associates with increased cancer risk particularly leukemias where genomic instability is a prominent feature. Additionally its relationship with FANCD2 within the Fanconi anemia pathway correlates SNM1A with Fanconi anemia-related disorders which showcase increased fragility and cancer susceptibility.