Abcam, ab227643, Anti-KRT6C antibody [SP87]

Size: 100µL / 500µL / 1mL
Rabbit Recombinant Monoclonal K2C6C antibody. Suitable for Flow Cyt (Intra), WB, IHC-P, ICC/IF, IHC-Fr and reacts with Human, Mouse, Rat samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:SP87,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, IHC-Fr, Flow Cyt (Intra), ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from TCS by protein A/G., Storage buffer-pH: 7.6Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KRT6C also known as Keratin 6C is a type II cytokeratin involved mechanically in structural support and protection in epithelial tissues. The protein has a molecular mass of approximately 59-60 kDa. It is mainly expressed in stratified epithelia including the skin mucosal linings and other keratinized surfaces. KRT6C provides resilience and strength to cells by forming keratin intermediate filaments that create a robust cytoskeletal network.
Biological function summary
Within various stratified epithelial tissues KRT6C ensures cellular integrity and facilitates protection against mechanical stress. As part of the keratin intermediate filament protein family KRT6C often interacts with other keratins typically forming complexes with KRT16 and KRT17 which enhance cell stability and responsiveness to damage. This protein plays a role in wound healing and cellular proliferation.
Pathways
KRT6C participates in several key biological processes including wound healing and the stress response pathway. In these pathways KRT6C functions closely with other proteins such as KRT16 which modulates cellular responses to environmental stressors and helps repair the epithelial barrier. The integration of KRT6C in these pathways highlights its importance in maintaining epithelial health and facilitating rapid response to injury.
KRT6C has significant connections with pachyonychia congenita a rare genetic disorder characterized by nail dystrophy and thickened skin. This condition often involves mutations in the KRT6C gene disrupting its interaction with KRT16 and KRT17 which compromises structural integrity of the skin and nail tissues. Furthermore KRT6C has implications in psoriasis a chronic inflammatory skin disorder where its altered expression may influence disease progression or severity.