Abcam, ab227920, Anti-KLF9 antibody

Size: 100µL
Rabbit Polyclonal KLF9 antibody. Suitable for IHC-P, IP, WB and reacts with Mouse, Rat, Human samples. Cited in 29 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF9.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human KLF9.Q13886

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KLF9 also known as Krüppel-like factor 9 is a transcription factor with a molecular weight of approximately 28-35 kDa. It is part of the Krüppel-like factor family and is recognized for its zinc finger DNA-binding motifs. KLF9 is expressed in various tissues including the liver brain lungs and reproductive organs. The expression suggests an important role in multiple physiological processes that require careful gene regulation.
Biological function summary
KLF9 serves as a regulator for growth-related and stress-responsive genes impacting cellular differentiation and proliferation. It does not typically form part of larger protein complexes but acts as a direct transcriptional regulator. KLF9 can repress or activate target genes depending on the context influencing processes such as glucose metabolism and neurological development. Its expression patterns notably adjust in response to hormonal signals particularly those involving thyroid hormone.
Pathways
KLF9 is involved in several important biological contexts including the Wnt signaling pathway and glucocorticoid signaling pathway. In these settings it regulates and collaborates with proteins like β-catenin and glucocorticoid receptors. This regulation affects cell fate determination differentiation and homeostasis. The interactions imply KLF9's broader role in controlling cellular responses to environmental changes and developmental signaling.
KLF9 has shown connections to neurological disorders such as epilepsy and metabolic conditions like obesity. Dysfunction in KLF9 regulation can influence these diseases through its impact on neurogenic transcription factors and metabolic genes. KLF9's interactions with proteins such as PPARγ in metabolic contexts or with RE1-Silencing Transcription Factor (REST) within neurological frameworks highlight its involvement in pathophysiological changes.