Abcam, ab228496, Anti-RFRP antibody

Size: 50µL
Guinea pig Polyclonal RFRP antibody. Suitable for IHC-Fr and reacts with Sheep samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NPVF aa 100-150 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Guinea pig,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Sheep,
Applications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NPVF aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9HCQ7

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 50µL, Purity-Whole antiserum, Storage buffer-pH: 7 - 7.4, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RFRP also known as RFamide-related peptide ranges in mass from 1.38 kDa to 2.85 kDa depending on the specific peptide variant. RFRP is expressed in the central nervous system particularly in the hypothalamus and pituitary gland and also found within the testis and ovary tissues. It originates from the VGF peptide precursor and plays a role in modulating various physiological processes.
Biological function summary
The RFamide-related peptide influences reproductive functions such as the regulation of gonadotropin release. It functions as an inhibitory factor on the secretion of gonadotropin-releasing hormone (GnRH) working in tandem with other neuropeptides and factors. RFRP is not a part of a larger complex but interacts closely with related neurohormones to exert its physiological effects.
Pathways
Several neuroendocrine control systems involve the RFamide-related peptide. RFRP plays an important role in the hypothalamic-pituitary-gonadal (HPG) axis where it modulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It interacts with receptor proteins like GPR147 which influences these essential pathways and subsequently affects reproductive system functionality.
The RFamide-related peptide has links to reproductive health issues such as delayed puberty and infertility. Abnormal activities or levels of RFRP can interfere with hormonal balance making it a potential target for addressing these reproductive system disorders. Additionally its regulation of GnRH suggests possible connections to disorders involving altered hormonal cycles including polycystic ovary syndrome (PCOS) where excessive or insufficient RFRP activity can disrupt cyclical hormone release patterns.