Abcam, ab228589, Anti-PACSIN2 antibody

Size: 100µL
Rabbit Polyclonal PACSIN2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Protein kinase C and casein kinase substrate in neurons protein 2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Protein kinase C and casein kinase substrate in neurons protein 2. The exact immunogen used to generate this antibody is proprietary information.Q9UNF0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PACSIN2 also known as Protein kinase C and casein kinase substrate in neurons protein 2 is a protein encoded by the PACSIN2 gene. This protein has a mass of approximately 54 kDa and functions primarily in the cytoplasm. PACSIN2 is expressed in various tissues with notable expression in the brain and kidney. This protein plays a role in skeletal muscle regulation by interacting with actin and promoting changes in cell shape. PACSIN2 also contributes to the process of endocytosis particularly in coordinating the assembly of proteins that form vesicles.
Biological function summary
PACSIN2 regulates cytoskeletal dynamics and membrane trafficking. It acts as a part of a protein complex that includes dynamin which is essential for the fission of vesicular membranes from the plasma membrane during endocytosis. Through its involvement in these processes PACSIN2 assists in maintaining cellular morphology and transport mechanisms within cells. Its interaction with dynamin and actin indicates its role in modulating cellular infrastructure during response to environmental changes or cellular signals.
Pathways
PACSIN2 participates in the endocytic pathway and the regulation of cytoskeletal dynamics. It interacts with proteins like dynamin important in vesicle scission during endocytosis. Moreover PACSIN2 influences pathways related to actin dynamics and cellular morphology changes interacting with actin to coordinate cytoskeletal rearrangements. This involvement highlights its function in cellular adaptation to different stimuli.
PACSIN2 is associated with neurodegenerative diseases and cancer. Research has shown its potential involvement in Alzheimer's disease due to its role in membrane trafficking and signaling pathways. In the context of cancer its expression may correlate with abnormal cell proliferation and tumor progression. The interaction between PACSIN2 and dynamin further links it to these disorders as alterations in endocytosis and signaling can affect disease progression and cell growth.