Abcam, ab228683, Anti-NTE antibody - C-terminal

Size: 100µL
Rabbit Polyclonal NTE antibody. C-terminal. Suitable for WB, IHC-P and reacts with Rat, Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PNPLA6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PNPLA6. The exact immunogen used to generate this antibody is proprietary information.Q8IY17

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein Neuropathy Target Esterase (NTE) also known as PNPLA6 is an important enzyme that catalyzes the hydrolysis of specific phospholipids. This enzyme is approximately 150 kDa in mass. It is widely expressed in neuronal tissues but is found in various other tissues such as liver and kidneys as well. By removing specific side groups from phospholipids NTE regulates lipid metabolism and membrane dynamics which is essential for maintaining cellular function and integrity.
Biological function summary
The Neuropathy Target Esterase functions in the detoxification of neuropathic organophosphates and plays critical roles in neural development and maintenance. NTE is part of a complex involved in the regulation of membrane phospholipid homeostasis. This complex acts to monitor and maintain the composition of membranes which is important for cell signaling and adhesion processes. The absence or malfunction of NTE can lead to disruptions in these processes indicating its importance in normal neuronal activity.
Pathways
NTE participates in phospholipid biosynthesis and degradation pathways. It interacts with proteins involved in membrane trafficking and signaling such as phospholipase D. These pathways are critical for lipid signaling and membrane dynamics linking NTE to key processes in cellular communication and response. NTE's association with these pathways emphasizes its role in maintaining lipid balance and cellular communication through its enzymatic activity.
NTE mutations or dysfunctions connect to complex conditions such as hereditary spastic paraplegia and motor neuron disease. These mutations can disrupt its known interactions with proteins like REEP1 and spastin within the nerve cells. Such conditions often involve the degeneration of motor neurons leading to progressive motor dysfunction. Understanding NTE's role in these diseases may provide insights for therapeutic interventions targeting these neurodegenerative disorders.