Abcam, ab229121, Anti-TIP150 antibody

Size: 100µL
Rabbit Polyclonal TIP150 antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MTUS2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MTUS2. The exact immunogen used to generate this antibody is proprietary information.Q5JR59

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TIP150 also known as TACC4 is a protein involved in the regulation of microtubule dynamics and centrosome function. TIP150 has an estimated molecular mass of around 150 kDa. Researchers find TIP150 mostly localized in the cytoplasm and nucleus within various types of cells including those in the brain and testis. This protein acts as an essential regulator of microtubule processes interacting directly with spindle apparatus components during cell division.
Biological function summary
TIP150 is a component of the mitotic spindle and contributes significantly to chromosome segregation and mitotic spindle stabilization. It forms part of the kinesin-13 associated protein complex where it helps control microtubule plus-end dynamics. As a result TIP150 supports the proper alignment and attachment of chromosomes to spindle microtubules during mitosis. Proper function is critical for accurate chromosome segregation which prevents aneuploidy.
Pathways
TIP150 plays an instrumental role in both the cell cycle and spindle assembly pathways. It associates with proteins such as KIF2C (also known as MCAK) a motor protein critical for microtubule depolymerization. This interaction is key to ensuring microtubule stability and proper mitotic spindle dynamics. Through these pathways TIP150 integrates into broader regulatory networks that sustain genomic stability during cell division.
TIP150 has connections to cancer and neurological disorders. Misregulation or mutation of TIP150 may contribute to tumorigenesis often linked with abnormal spindle function and chromosome missegregation. TIP150 also associates with KIF2C which when dysregulated similarly associates with cancer susceptibilities. Neurologically studies suggest TIP150 expression changes may be related to neuronal cell cycle re-entry a process implicated in neurodegenerative diseases. Such alterations in TIP150 regulation may lead to cellular events contributing to diseases like Alzheimer’s.