Abcam, ab229896, Anti-GSDMC2 + GSDMC3 antibody [EPR20890-48]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal GSDMC2 antibody. Suitable for mIHC, WB, IHC-P, IHC-Fr and reacts with Mouse, Human, Transfected cell lysate - Mouse samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20890-48,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, IHC-Fr, IHC-P, mIHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GSDMC2 and GSDMC3 known as Gasdermin C2 and C3 belong to the gasdermin family of proteins. These proteins exist as components involved in membrane permeabilization and play a role in cell pyroptosis. GSDMC2 and GSDMC3 have masses of approximately 53 kDa and 54 kDa respectively. They are expressed in a range of tissues with significant levels identified in lung colon and stomach tissues. Their location within cells suggests involvement in inflammatory responses due to activity upon cleavage by inflammatory caspases.
Biological function summary
GSDMC2 and GSDMC3 participate in the promotion of pyroptosis a form of programmed cell death associated with inflammation. Upon cleavage by caspases these proteins can form pores in cell membranes leading to cell lysis. GSDMC2 and GSDMC3 are not typically associated with forming larger protein complexes but they are part of the defense responses that cells undertake under pathogen attack or stress signaling danger to the immune system and aiding in the clearance of infected cells.
Pathways
GSDMC2 and GSDMC3 are integrally involved in the inflammatory signaling and response pathways. They notably participate in the pathways regulating pyroptosis specifically reacting to inflammatory caspases like caspase-1 and caspase-11 which activate them to induce cell death. The proteins function alongside other gasdermin family members in the pyroptotic process particularly with proteins like NLRP3 inflammasome which initiates the cascade resulting in their activation.
GSDMC2 and GSDMC3 have implications in conditions like inflammatory bowel disease (IBD) and colorectal cancer due to their role in uncontrolled inflammation and cell turnover. Aberrant regulation of these proteins and their pathways can lead to chronic inflammation contributing to such diseases. In the context of these conditions GSDMC2 and GSDMC3 are observed to have interactions with proteins like IL-1β an important inflammatory cytokine highlighting their connection in pathogenesis and potential therapeutic interventions.