Abcam, ab230008, Anti-KANSL1 antibody

Size: 50µL
Rabbit Polyclonal KANSL1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KANSL1 aa 800-1100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KANSL1 aa 800-1100. The exact immunogen used to generate this antibody is proprietary information.Q7Z3B3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KANSL1 also known as KAT8 Regulatory NSL Complex Subunit 1 plays a significant role in the regulation of gene expression by acetylating histone H4. The protein has a molecular mass of approximately 114 kDa. It is widely expressed in different tissues with higher levels in the brain heart and skeletal muscle. This expression pattern suggests it has broad regulatory roles in diverse physiological processes.
Biological function summary
KANSL1 functions as a part of the comprehensive NSL chromatin-modifying complex. This complex regulates the transcriptional activation of specific genes by modifying chromatin structure which affects RNA polymerase II activity and gene expression. Through its acetylation activity KANSL1 impacts processes like cell cycle progression cellular differentiation and development. The interaction of KANSL1 with chromatin highlights its central importance in maintaining normal cellular states.
Pathways
The functional activity of KANSL1 connects to several important biological pathways including the DNA damage response and cell cycle pathways. KANSL1 works in conjunction with other proteins like KAT8 and MSL1 to coordinate precise genetic responses to environmental and cellular signals. These pathways ensure genomic stability and proper cell division reflecting the role of KANSL1 in critical cellular processes.
Research has linked KANSL1 to the neurological condition Koolen-de Vries Syndrome (KdVS). KdVS arises due to mutations that affect KANSL1 leading to developmental delays and intellectual disabilities. Furthermore KANSL1's connections with neurodevelopmental proteins such as MBD5 underline its importance in normal brain function. Investigating KANSL1 offers insights into understanding and potentially addressing conditions stemming from its dysfunction.