Abcam, ab230478, Anti-MYO6 antibody

Size: 50µL
Rabbit Polyclonal MYO6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human MYO6 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MYO6 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9UM54

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.01% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MYO6 also known as Myosin VI functions as a motor protein that moves towards the minus end of actin filaments. It has an approximate molecular mass of 140 kDa. MYO6 can express in various tissues including the inner ear and the cytoplasm of cells. Its unique ability to move in the opposite direction compared to other myosins makes it essential for processes like endocytosis and membrane trafficking.
Biological function summary
Myosin VI interacts with actin filaments to enable cellular processes like endocytosis autophagy and maintaining Golgi complex structure. MYO6 often part of a protein complex manages intracellular transportation and organelle positioning. By interacting with several binding partners it regulates the mechanical tension within cells contributing to cell shape and movement.
Pathways
The role of Myosin VI integrates with cell signaling and intracellular transport pathways. In the endocytic pathway it associates with proteins such as Dab2 and GIPC aiding in clathrin-mediated endocytosis. Myosin VI also participates within the autophagy pathway influencing cellular stress responses. These interactions demonstrate its involvement in the dynamic coordination of cellular components.
Abnormalities in MYO6 are linked to sensorineural hearing loss and forms of cancer. Mutations can lead to defects in cell maintenance and motility contributing to these conditions. In cancer Myosin VI may interact with proteins like E-cadherin affecting cell adhesion and metastasis. Understanding Myosin VI's connections to these diseases offers insights into possible therapeutic targets.