Abcam, ab230520, Anti-TUSC3 antibody

Size: 50µL
Rabbit Polyclonal TUSC3 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TUSC3 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TUSC3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q13454

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.01% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TUSC3 also known as Tumor Suppressor Candidate 3 is a protein weighing approximately 42 kDa. It plays a role in N-glycosylation an important post-translational modification mechanism. TUSC3 is mainly expressed in the human endoplasmic reticulum and is involved in protein folding processes. By aiding in this process TUSC3 supports the correct functioning of proteins throughout the cell. Within the endoplasmic reticulum it serves as part of a complex that ensures proper protein maturation.
Biological function summary
The protein involves itself in an important role in the cellular mechanism of N-glycosylation. TUSC3 associates with the oligosaccharyltransferase complex facilitating the transfer of oligosaccharides to nascent proteins. This process enhances the stability and function of many proteins that require glycosylation. TUSC3's proper activity ensures the correct folding and functionality of these glycoproteins impacting cell homeostasis and viability.
Pathways
TUSC3 functions within both the N-glycosylation pathway and the unfolded protein response (UPR). Its activity in N-glycosylation ensures proteins are correctly folded and functional while its role in the UPR helps manage cellular stress by promoting the proper folding of proteins under stress conditions. TUSC3 works closely with proteins like calnexin in these pathways collaborating to maintain protein quality control and reduce potential cellular dysfunction.
TUSC3 links to certain cancers and neurological conditions. Its role as a tumor suppressor implicates it in various cancers where reduced expression can lead to tumor progression. Additionally mutations or dysfunctions in TUSC3 have been associated with intellectual disabilities where glycosylation deficiencies contribute to disease pathology. TUSC3 interacts with proteins such as alpha-dystroglycan in these contexts where alterations can disrupt normal cellular functions and lead to disease development or progression.