Abcam, ab230522, Anti-CASC4 antibody - C-terminal

Size: 200µL
Rabbit Polyclonal CASC4 antibody. C-terminal. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GOLM2 aa 300-400 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GOLM2 aa 300-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q6P4E1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CASC4 short for Cancer Susceptibility Candidate 4 is a protein involved in cell processes with a mass of approximately 87 kDa. It is expressed in various tissues with higher levels observed in specific cancer types. Its exact mechanical role in cells includes interactions and binding to other cellular elements influencing cell functions and stability. Researchers usually study this protein by its official name due to its relevance in cancer studies and its interaction potentials in cellular mechanisms.
Biological function summary
The protein plays a role in cellular growth and regulation. It is part of a larger complex that includes other signaling and structural proteins supporting its function in maintaining proper cellular environments. It may help ensure the cell cycle progresses smoothly influencing cell survival and replication. Its expression suggests it might help modulate responses under stress or during abnormal growth which can have implications for understanding certain cancer behaviors.
Pathways
CASC4 engages in cellular signaling and growth regulation pathways specifically those related to cancer biology. It is involved in pathways such as the PI3K/AKT pathway which is important for cell proliferation and survival. In these networks CASC4 connects with other proteins like AKT potentially influencing the pathway’s outcomes on cell fate decisions and tumor progression. This interaction suggests that CASC4 may have a role in modifying signaling outcomes depending on different cellular contexts.
Research indicates that CASC4 is associated with cancer progression and certain subtypes like breast and colorectal cancers. These associations hint that abnormal expression or functioning of CASC4 could contribute to oncogenic processes. It often interacts with proteins like PTEN in these disease contexts emphasizing its potential impact on tumor suppression or promotion. Understanding these interactions could prove beneficial in developing targeted therapies or diagnostic markers for these cancers.