Abcam, ab230538, Anti-CTC1 antibody

Size: 200µL
Rabbit Polyclonal CTC1 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CTC1 aa 750-800 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CTC1 aa 750-800 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q2NKJ3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTC1 also known as CTS or conserved telomere maintenance component 1 is a protein with a mass of approximately 145 kDa. This protein is expressed in a variety of tissues including those with high cellular proliferation rates such as bone marrow and intestinal crypts. CTC1 is a core component of the CST complex which also consists of STN1 and TEN1. This complex plays an important role in maintaining telomere integrity by stabilizing telomeric DNA and facilitating telomere end protection.
Biological function summary
The CST complex that includes CTC1 serves as a mediator in the process of telomere replication. CTC1 specifically helps prevent telomere shortening and genomic instability by acting during the final stages of DNA replication. It independently ensures that single-strand overhangs at the telomere ends do not become excessively long. The CTC1 protein is particularly involved in preventing telomere degradation by negatively regulating the activity of telomerase an enzyme responsible for extending telomeres.
Pathways
CTC1 integrates into the telomere maintenance and DNA replication pathways. The CST complex works closely with POT1 and TPP1 proteins important elements of the shelterin complex to form a protective cap on chromosome ends. This interaction coordinates the transition from replication to proper telomere sealing. Furthermore CTC1 collaborates with DNA polymerase α to manage proper telomere length and integrity throughout the cell cycle ensuring genomic stability.
Mutations or dysregulation in CTC1 have been implicated in conditions such as Coats plus syndrome and dyskeratosis congenita. These diseases highlight CTC1's role in maintaining telomere integrity and genomic stability. In particular Coats plus syndrome associates with reduced function of CTC1 affecting tissues with high turnover rates. The involvement of STN1 and TEN1 in these disorders emphasizes the critical function of the entire CST complex where deficient CTC1 activity disrupts their stabilizing role at telomeres.