Abcam, ab230663, PE Anti-ILT-7 antibody [17G10.2]

Size: 100Test
Mouse Monoclonal ILT-7 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:17G10.2,
Isotype:IgG1,
Conjugation:PE,
Excitation/Emission:Ex: 480;565nm, Em: 578nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Size-exclusion chromatography, Purification notes-Purified from TCS. Purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary., Storage buffer-pH: 7.4Preservative: 0.0975% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ILT-7 also known as LILRA4 is an important receptor involved in the immune response. It is expressed on plasmacytoid dendritic cells and holds significant weight approximately 38 kDa. The receptor is part of the immunoglobulin-like transcript family containing unique extracellular domains that interact with specific ligands. ILT-7 is known for its role in mediating signals that shape the behavior of immune cells particularly in antiviral defenses.
Biological function summary
ILT-7 plays an important role in the regulation of type I interferon production in dendritic cells. This receptor forms a complex with the Fc epsilon RI gamma chain which transmits activation signals inside the cell. In resting conditions ILT-7 helps maintain immune homeostasis by regulating the release of interferons therefore balancing immune activation and controlling potential overactivity that might lead to autoimmunity.
Pathways
ILT-7 interacts within the signaling network of toll-like receptor (TLR) pathways. It closely ties with TLR9 a protein that recognizes unmethylated CpG motifs often found in viral DNA enhancing the production of interferons during viral infections. This collaboration establishes a link between pathogen recognition and immune response modulation within dendritic cells assisting in orchestrating a potent defense against viral pathogens.
ILT-7 has connections to systemic lupus erythematosus and chronic viral infections. Dysregulation of ILT-7 expression or function can lead to excessive interferon production contributing to the pathology of lupus. In chronic viral infections ILT-7 interaction with proteins like TLR9 and the subsequent dysregulation can support viral persistence or worsen disease outcomes by altering immune responses. Understanding ILT-7’s roles offers insights into therapeutic targets for modulating immune response in these diseases.