Abcam, ab230879, Anti-HOXA3 antibody - C-terminal

Size: 200µL
Rabbit Polyclonal HOXA3 antibody. C-terminal. Suitable for WB, IHC-P, Flow Cyt (Intra) and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human HOXA3 aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HOXA3 aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O43365

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXA3 also known as Homeobox A3 is a transcription factor involved in the regulation of gene expression. It serves key roles in the development and differentiation processes. With a molecular weight of approximately 35 kDa it is a member of the Homeobox gene family. HOXA3 expression occurs mainly in embryonic tissues predominantly in regions such as the hindbrain neural crest cells and vascular structures. The gene's expression is important for establishing the anterior-posterior axis and guiding proper morphogenetic processes during early development.
Biological function summary
HOXA3 contributes to the establishment of body maps by regulating target genes involved in developmental patterning. It acts as part of the homeotic gene complex which includes other HOX genes essential for segmental organization during embryogenesis. As a transcription factor HOXA3 binds to specific DNA sequences to control the expression of genes that direct the development of specific segments of the body. This function underpins its critical role in shaping the vertebrate body plan and influences the differentiation of cells within these segments.
Pathways
HOXA3 plays an integral role in pathways like the Hedgehog and Wnt signaling pathways which are essential for developmental processes. These pathways allow interactions with proteins such as HOXB and HOXD clusters reinforcing the segmental identity during embryo development. HOXA3 maintains proper regulation in these pathways ensuring correct gene expression patterns contributing to successful organogenesis and morphogenesis.
HOXA3 has been connected to congenital malformations and certain types of cancers. Mutations or dysregulation in its expression contribute to disorders such as congenital hypothyroidism. Moreover its aberrant expression links to tumor development where it may interplay with proteins like TP53 influencing cancer progression. Understanding the impact of HOXA3 in these pathways offers potential insights into developing targeted therapeutic strategies.