Abcam, ab231030, Anti-Warp antibody

Size: 100µg
Rabbit Polyclonal Warp antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human von Willebrand factor A domain-containing protein 1 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human von Willebrand factor A domain-containing protein 1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q6PCB0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography, Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Warp also known as Wind and Recovery Protein plays a role in cytoskeletal arrangement and cellular architecture. This protein has an approximate molecular mass of 55 kDa and is highly expressed in neuronal tissues particularly in areas of the brain responsible for signal transmission. Warp associates with microtubules aiding in their stabilization and dynamics. It has a signature sequence that interacts with tubulin contributing to its regulatory functions within the cell.
Biological function summary
Warp interacts with cytoskeletal networks to maintain cellular structure and support cellular transport. It becomes part of a larger protein complex that facilitates microtubule assembly. The protein plays a significant role in neuronal cells supporting axonal transport which is essential for nerve function. Warp's involvement in maintaining dynamic microtubules suggests its potential influence on cellular processes that require robust structural integrity and adaptability.
Pathways
Warp is integral to the MAPK signaling pathway and is an important player in intracellular transport operations. By participating in this pathway Warp influences cellular reactions to external stimuli. It also interfaces with proteins such as MAPK and kinesin which are critical to signal transduction and movement along microtubules respectively. These interactions help modulate cellular responses and maintain efficient cellular trafficking.
Research highlights Warp's role in neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. Dysfunction in Warp's regulation of the cytoskeleton can lead to impaired axonal transport contributing to neuronal degeneration seen in these disorders. The protein has a connection with tau a protein implicated in the aggregation seen in Alzheimer's pathology. Disruptions in Warp-tubulin interactions can exacerbate the progression of these neurodegenerative diseases pointing to the potential of Warp as a target for therapeutic intervention.