Abcam, ab231119, Anti-Pancreatic alpha amylase antibody

Size: 100µg
Rabbit Polyclonal AMYP antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pancreatic alpha amylase also known as AMY2A is an enzyme responsible for catalyzing the hydrolysis of starch into sugars. This enzyme is an important amylase protein with a molecular mass of approximately 56 kDa. It is abundantly expressed in the pancreas of mammals playing a significant role in the digestive process. The product of its activity maltose contributes to carbohydrate digestion allowing for energy production in the body.
Biological function summary
Pancreatic alpha amylase assists in the breakdown of large polysaccharides into smaller maltose units. This enzyme can act independently and does not require a complex to function effectively. It carries out its activity primarily in the small intestine where it continues the digestive process initiated by salivary alpha amylase. This amylase protein ensures that starches consumed in the diet are converted into forms absorbable by the body contributing to overall metabolism.
Pathways
Pancreatic alpha amylase is a critical enzyme in the digestive pathway especially in the carbohydrate digestion and absorption pathway. Its activity complements that of other amylase enzymes including salivary alpha amylase to ensure efficient starch breakdown. Additionally pancreatic alpha amylase works in conjunction with proteins like glucose transporters which facilitate the entry of glucose into cells after starch breakdown.
The activity of pancreatic alpha amylase often links to conditions such as pancreatitis and type 2 diabetes. Elevated levels of this enzyme in the bloodstream can indicate acute pancreatitis highlighting its significance in diagnosing this disorder. In the context of diabetes altered pancreatic amylase activity can affect glucose metabolism. The enzyme's association with glucose-regulating proteins such as insulin makes it a focal point in understanding diabetic pathophysiology.