Abcam, ab231229, Anti-MGAM antibody

Size: 100µg
Rabbit Polyclonal MGAM antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MGAM aa 200-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MGAM aa 200-400. The exact immunogen used to generate this antibody is proprietary information.O43451

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MGAM or maltase-glucoamylase is an important enzyme in carbohydrate digestion. This protein with a mass of approximately 185 kDa functions primarily in the small intestine where it acts on oligosaccharides breaking them down into glucose units. MGAM exhibits substrate specificity cleaving alpha-14-glycosidic linkages and assisting in the final steps of starch digestion. The enzyme exists in brush-border membranes and demonstrates similar activity to another enzyme sucrase-isomaltase.
Biological function summary
Maltase-glucoamylase plays a significant role in nutrient absorption by facilitating glucose release which is necessary for energy production. It associates with the brush-border membrane in enterocytes aiding digestive processes. It does not typically form part of a larger protein complex but works in tandem with other digestive enzymes. Its activity ensures efficient breakdown of carbohydrates influencing nutritional uptake and metabolic balance.
Pathways
Maltase-glucoamylase participates in the starch and sucrose metabolism pathway. Its enzymatic action represents a final step in this digestive pathway leading to the absorption of glucose the primary energy source. MGAM works alongside sucrase-isomaltase which also contributes to breaking down dietary carbohydrates into absorbable monosaccharides. This coordinated activity ensures effective carbohydrate digestion and nutrient assimilation.
Maltase-glucoamylase's function can affect conditions such as carbohydrate malabsorption and type 2 diabetes. Deficiencies or abnormalities in MGAM activity can lead to compromised carbohydrate digestion resulting in gastrointestinal symptoms. The enzyme's role in glucose release also ties it to metabolic conditions as improper glucose management influences the onset of type 2 diabetes. Interaction with proteins such as insulin can modulate these effects indicating the enzyme's significance in metabolic health.