Abcam, ab231632, Anti-Grancalcin antibody

Size: 100µg
Rabbit Polyclonal Grancalcin antibody. Suitable for WB, IHC-P and reacts with Human, Recombinant full length protein - Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GCA aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GCA aa 1-150. The exact immunogen used to generate this antibody is proprietary information.P28676

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab231632 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Grancalcin also known as GCL or GCA is a calcium-binding protein that belongs to the penta-EF-hand family. The protein has a molecular mass of about 24 kDa. It is predominantly found in neutrophils and monocytes where it localizes to the cytosol and cell membrane upon calcium activation. Grancalcin is known for its role in calcium signaling as its function is calcium-dependent which aids in modulating cellular processes.
Biological function summary
Grancalcin is involved in the regulation of cellular adhesion mechanisms. It does not form part of a larger protein complex but it plays a critical role in integrating calcium signals that facilitate cell function. Additionally grancalcin helps in the reorganization of the cytoskeleton impacting processes like chemotaxis and phagocytosis important for immune response.
Pathways
Grancalcin plays a role in the integrin signaling pathway. It interacts with key proteins in this pathway such as talin and vinculin to mediate cell adhesion and motility. Grancalcin's regulation of calcium signals also ties it to the MAPK signaling pathway which influences various cell functions including proliferation and differentiation.
Alterations in grancalcin expression or function have connections to immune-related diseases such as chronic inflammation. Aberrant levels may also have implications in cancer metastasis where cell adhesion and motility affect tumor spread. Grancalcin's role in these conditions may involve interactions with integrin-associated proteins that modulate the mechanical properties of cells.