Abcam, ab231802, Anti-ACTG2 antibody

Size: 100µg
Rabbit Polyclonal ACTH antibody. Suitable for WB, IHC-P and reacts with Human, Recombinant full length protein - Human, Rat, Pig samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ACTG2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human, Pig,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ACTG2.P63267

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab231802 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ACTG2 protein also known as gamma-2 actin plays a role in the mechanical structure and function of muscle tissues. It is a part of the actin family of proteins which are essential components of the cytoskeleton. ACTG2 has a molecular mass of approximately 42 kDa. This protein is expressed mainly in smooth muscles where it contributes to the structural integrity and contractile function by forming actin filaments.
Biological function summary
The ACTG2 protein is critical in maintaining and regulating the contractility of smooth muscle tissues. It does so by being part of the thin filament complex that interacts with myosin for muscle contraction. This complex is essential for the normal functioning of various organs such as blood vessels gastrointestinal tract and respiratory tract which require smooth muscle contraction for their operation.
Pathways
ACTG2 is integral to the contractile mechanism pathways of smooth muscle cells. It participates in the actin-myosin interaction that converts chemical energy into mechanical work a process essential for muscle contraction in smooth muscle tissue. This actin protein relates to other contractile proteins like myosin heavy chain and tropomyosin which are important within these pathways for effective muscle function.
ACTG2 mutations have connections to visceral myopathy and other types of smooth muscle dysfunctions. Visceral myopathy affects the smooth muscle tissues of the gastrointestinal tract leading to issues like chronic intestinal pseudo-obstruction. In this context ACTG2 mutations can affect interactions with proteins like myosin disrupting contractility and resulting in such disorders.