Abcam, ab231958, Anti-Pericentrin 1/FROUNT antibody

Size: 100µg
Rabbit Polyclonal Pericentrin 1/FROUNT antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Nup85 aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Nup85 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8R480

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pericentrin also known as FROUNT is a protein that plays a critical role in organizing microtubule arrays inside cells. It exhibits a molecular mass of approximately 360-400 kDa. This protein localizes mainly at the centrosome an important cellular structure involved in microtubule nucleation as well as at basal bodies within cilia. In centrosomes Pericentrin serves as an anchoring point for several other proteins which helps in maintaining centrosome integrity and supporting cell division processes.
Biological function summary
Pericentrin helps coordinate the microtubule network facilitating essential cellular events such as mitosis and intracellular transport. As part of a larger protein complex Pericentrin interacts with gamma-tubulin and several other centrosomal proteins to enhance microtubule nucleation. Additionally Pericentrin helps stabilize the microtubule organizing center ensuring proper cell cycle progression and cellular architecture.
Pathways
Pericentrin plays a role in the centrosome cycle and mitotic spindle assembly. It interacts with proteins like CEP152 and CDK5RAP2 which are important for proper centrosome duplication and function. These interactions contribute to pathways involved in cell division particularly the regulation of the mitotic spindle and chromosome stability during cell division.
Pericentrin mutations or dysfunctions have been linked to conditions such as microcephalic osteodysplastic primordial dwarfism and certain cancers. Its role in centrosome integrity ties it to BRCA1 a protein associated with breast and ovarian cancer susceptibility. Disrupted Pericentrin function can lead to abnormal cell division and aneuploidy which are common features in cancerous growths.