Abcam, ab232610, Anti-Bok antibody [EPR15331] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal BOK antibody. Carrier free. Suitable for IP, WB and reacts with Human, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15331,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab232610 is the carrier-free version of
ab186745
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BCL2-related ovarian killer (Bok) is a pro-apoptotic member of the Bcl-2 protein family contributing to apoptosis regulation. Bok sometimes referred to by its weight as approximately 23-25 kDa facilitates programmed cell death through mitochondrial pathways. Researchers have identified its expression primarily in reproductive tissues like ovaries and testis with some presence in the liver. Bok interacts with other Bcl-2 family proteins which act as apoptosis regulators creating a balance between cell survival and death.
Biological function summary
Bok plays an important role in the intrinsic apoptosis pathway by modulating mitochondrial outer membrane permeabilization. Bok forms protein complexes with other Bcl-2 family members like Bax and Bak contributing to cytochrome c release. This release is important for the activation of caspases leading to cellular apoptosis. Bok also exercises a regulatory role on calcium homeostasis within cells although its exact mechanisms remain under study.
Pathways
Bok integrates into the mitochondrial apoptosis pathway and the endoplasmic reticulum stress response influencing cellular fate decisions. Within these pathways Bok interacts with proteins such as Bax Bak and Bcl-2 balancing pro-apoptotic and anti-apoptotic signals. Bok's ability to influence these pathways demonstrates its importance in maintaining cellular homeostasis and response to stress signals.
Bok has been associated with cancer and neurodegenerative diseases. Its role in promoting apoptosis links it to conditions where apoptosis is dysregulated such as tumorigenesis where reduced Bok activity could contribute to cancer progression. In neurodegenerative disorders like Alzheimer's Bok's interaction with proteins like Bax may exacerbate neuronal loss through increased apoptosis emphasizing the need for understanding Bok in developing therapeutic strategies.