Abcam, ab232615, Anti-ACAP2 antibody [EPR15721] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ACAP2 antibody. Carrier free. Suitable for WB, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15721,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab232615 is the carrier-free version of
ab191424
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACAP2 also known as ArfGAP with coiled-coil ankyrin repeat and PH domain-containing protein 2 plays a role in cell signaling and membrane trafficking. It has a molecular mass of around 90 kDa and is expressed in various tissues including the brain and kidney. ACAP2 acts as a GTPase-activating protein (GAP) for ADP-ribosylation factor 6 (Arf6) a member of the Arf family which is important in vesicle formation in cellular processes.
Biological function summary
ACAP2 influences cellular processes by regulating actin cytoskeleton remodeling and endocytosis. It is part of a complex that interacts with proteins like phosphatidylinositol 45-bisphosphate which helps localize ACAP2 to specific cellular membranes. The protein's ability to bind and hydrolyze GTP enables changes in cell shape and movement contributing to cellular migration and morphological adjustments.
Pathways
ACAP2 participates in the endocytic pathway which is important for internalizing substances into the cell. It is also involved in the signaling pathway related to the actin cytoskeleton impacting cell motility. In these pathways ACAP2 interacts with proteins such as Arf6 facilitating its function as a regulator of endocytosis and actin dynamics.
ACAP2 has been linked to cancer and neurodegenerative diseases. Dysregulation of ACAP2 and its associated proteins like Arf6 can lead to changes in cell adhesion and motility processes often altered in tumor progression. Additionally aberrant ACAP2 function can interfere with normal neurological processes possibly contributing to the pathology of neurodegenerative disorders.